Nimesil granules for the preparation of suspension for oral administration 100 mg/2g in bags No. 30

Non-steroidal anti-inflammatory drugs are often used to relieve acute pain and eliminate symptoms of inflammation. Nimesil and its analogues are not first-line drugs and are recommended for use only if weaker drugs (paracetamol, diclofenac, ibuprofen) are ineffective.

According to the official instructions, Nimesil is a prescription medicine. Indications for use include moderate and severe pain of various origins (inflammatory, neurogenic, traumatic, postoperative), hyperthermia with chills, myalgia, dysmenorrhea.

Nimesil is sold in the form of a fast-dissolving granular powder, which before use must be dissolved in 150 ml of clean water to obtain an oral solution. This form of release provides the fastest possible therapeutic effect. Each sachet contains 100 mg of nimesulide, an NSAID that reduces the synthesis of inflammatory mediators such as prostaglandins, leukotrienes, and arachidonic acid. Thanks to this, it is possible to eliminate pain and reduce body temperature.

This powder is prohibited for use in the presence of such concomitant diseases as acute and chronic gastritis, duodenitis, duodenal and gastric ulcers, ulcerative colitis, aspirin-induced asthma, bleeding disorders, severe hepatic, hepatic and heart failure.

The official instructions for Nimesil provided by the manufacturer indicate that febrile fever and signs of influenza are contraindications to the use of this drug. Age limit – 12 years. The most common treatment regimen is 1 sachet as needed.

Cost of Nimesil and its analogues

Nimesil is an imported drug; it is produced by several pharmaceutical companies - Laboratorios Menarini (Italy) and Fine Foods & Pharmaceutical (Spain). This is one of the first nimesulide-based drugs registered in Europe. At the moment, a large number of generics have appeared on the market, which have the same clinical effect, but have a lower cost.

Cheap analogues of Nimesil in tablets

Thanks to its special release form, Nimesil has the fastest possible analgesic effect. In cases where it is not possible to prepare a solution (for example, on the road), it is more convenient to use similar drugs in tablets. They cost a little less than the original drug, but are also effective.

Nimulid

The drug is made in India and is produced by Panacea Biotek. It is most often used for the treatment of inflammatory diseases of the musculoskeletal system (myositis, arthritis, arthrosis), helps to quickly eliminate pain of various origins, including after surgery and injuries. A special feature is the presence of not only tablets for oral administration, but also a sublingual form, which is intended for resorption in the oral cavity. For children over 6 years of age, Nimulid is used in the form of a suspension. The maximum daily dose for adults is 200 mg, that is, 2 tablets; for children it is calculated individually based on the formula 5 mg/kg body weight. The duration of action of the drug is 5-6 hours.

It is a second-line drug, since in addition to a good analgesic effect, it can cause adverse reactions, has a toxic effect on the liver, and can provoke bleeding or a hypertensive crisis.

Aponil

Tablets registered in our country as an antirheumatic and non-steroidal anti-inflammatory drug. Produced by the European company Mekodemi LTD (Cyprus) in the form of tablets with a single dosage - 0.1 g of nimesulide. Each cardboard package contains 2 plastic cellular blisters of 10 tablets. Lactose monohydrate, sodium docusate, hydrogenated vegetable oil (palm or coconut), corn and potato starch, and microcellulose are used as auxiliary components in the production of Aponil. According to the recommendations of specialized associations for stepwise pain therapy, Aponil is used for relieved acute pain syndrome when other analgesics are ineffective. This medicine helps to quickly eliminate myalgia, arthralgia, headache and toothache.

The drug should not be used by children, pregnant or lactating women. Contraindications include alcoholism, aspirin-induced asthma, impaired detoxification function of the liver, chronic kidney disease, exacerbation of inflammatory and ulcerative diseases of the gastrointestinal tract.

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Most often the drug is used symptomatically, but if long-term pain relief is needed, 1 tablet is prescribed 2 times a day after meals. The duration of treatment is determined individually, taking into account the indications.

Nimika

A non-narcotic analgesic with anti-inflammatory and analgesic properties. Indicated for toothache, lumbodynia, neuritis, injuries. Can be used to relieve pain during surgical procedures in dentistry, as well as after surgical interventions.

It is produced in India by the pharmaceutical company Ipka in tablet form with a dosage of 0.05 and 0.1 mg of nimesulide. According to the instructions, before taking, you need to dissolve 1 or 2 tablets in a spoon of water. For adults, Nimika is prescribed 100 mg 2 times a day. For children, an oral suspension is used (10 mg of nimesulide in 1 ml), a single dose is calculated taking into account weight and age, on average 2 mg/kg.

Contraindications: allergy to acetylsalicylic acid and other NSAIDs, increased bleeding, acute heart failure, renal and liver failure.

Nimesulid-Teva

A modern analgesic whose chemical structure is a sulfonanilide. Inhibits the synthesis of prostaglandins, arachidonic acid, leukotrienes, thereby eliminating signs of inflammation such as pain, swelling, and fever. Quickly normalizes well-being in infectious and inflammatory diseases that are accompanied by intoxication and fever, and also eliminates neurogenic and traumatic pain.

Nimesulide-Teva affects the pharmacodynamic properties of a large number of drugs and is therefore not recommended for routine use. The drug is prohibited for use by pregnant and lactating women and children under 12 years of age. To eliminate pain or hyperthermia, in most cases, a single dose of the tablet is sufficient.

Nimesan

Manufactured in India by Shreya. Packages of 20 tablets at a dosage of 100 mg are available for sale. Purified microcellulose, potato starch, sodium stearate, and lactose are used as auxiliary substances in production. Nimesan tablets are quickly absorbed from the gastrointestinal tract, the effect is noticeable 15-20 minutes after administration and lasts up to 6 hours. Indications for use: severe pain that cannot be relieved by other NSAIDs.

Nimesan is not recommended for long-term treatment. If the dosage is exceeded, as well as frequent use of this medicine, undesirable reactions may occur - dizziness, sleep disturbances, nausea, vomiting, stool upset, abdominal pain. The drug is hepatotoxic; in case of liver failure, dose adjustment is necessary. Age limit – 12 years.

During pregnancy and lactation, taking Nimesan can have negative effects on the fetus and child, so you should give preference to safer drugs.

Price of funds

All of the above Nimesil analogues have completely identical ATS codes. The drugs are selected according to the chemical structure of the original and are the most suitable substitutes. And if not everyone can afford Nimesil due to its considerable cost, then the price of generics is quite acceptable.

But when choosing an analogue of Nimesil, you should not focus on price alone. The concentration of the active substance in generics should be equivalent to the original, and the dosage should deviate slightly up or down.

In addition, the amount of the drug required for the course of therapy must be taken into account. It is better if the doctor indicates the dosage form and the required amount of medication in the prescription.

It is strictly not recommended to self-medicate and buy untested medications with questionable composition. Some substitutes are absorbed slowly and incompletely from the intestines, automatically reducing their bioavailability.

Before you buy another drug instead of Nimesil, you must check its composition for the presence of unknown impurities.

The fact is that generics are rarely tested in laboratories (and if they are, it is in a simplified form), so the side effects may differ from those declared for Nimesil. The minimum concentration of nimesulide leads to a decrease in the effectiveness of treatment.

If the cost of a substitute is too low compared to the original medicine, it is better to refrain from purchasing it. There is a high probability that such a generic was produced on outdated equipment or that it is produced by a company about which little is known. The exception to this rule is European/Indian companies that have been producing medicines for more than half a century.

Nimesil analogues are a profitable alternative for people who want to quickly get rid of pain, but do not want to spend a lot of money on medications. Substitutes can be either in powder or in tablets. The choice in favor of one or the other depends on individual preferences and characteristics of the pathological condition.

Inexpensive substitutes for Nimesil powder

If you need to quickly eliminate pain or fever, it is rational to use the drug in powder. This ensures high bioavailability of the drug and the fastest possible clinical effect. Sachets containing a single dose can be purchased individually at pharmacies.

Nise

Belongs to the group of non-steroidal anti-inflammatory drugs. The active ingredient is nimesulide. The chemical properties are sulfonanilide, and the mechanism is associated with blocking type 2 cyclooxygenase receptors. Indicated for the treatment of lumbago, gout attacks, arthritis of various etiologies. The drug has a fairly large number of side effects, which is associated with high hepatotoxicity, therefore it is not recommended in routine practice and is a second-line therapy.

Produced by the pharmaceutical company Dr. Reddis, India. A special feature is the presence of several forms of release:

• Sachets of granulated powder for preparing a solution, 2g;
• Enteric tablets;
• Oral suspension.

The drug can be used by children over 7 years of age with strict adherence to the instructions and constant medical supervision.

Nemulex

The drug is packaged in the Russian Federation by Sotex PharmFirma, which carries out control before sale. Raw materials based on nimesulide are produced in Romania at the Rompharm Company plant.

Release form: dry powder in the form of granules. After dissolution in water, a homogeneous suspension with a pleasant orange taste and smell is formed. The drug is used as symptomatic treatment of diseases that are accompanied by severe pain - osteochondrosis, arthrosis and arthritis, bursitis, myalgia, toothache and headache, radicular syndrome. It is prohibited to use the drug during pregnancy and breastfeeding.

Possible adverse reactions include allergies, urticaria, dizziness, drowsiness, depressed emotional state, nausea, abdominal pain.

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Nimid

An anesthetic drug based on nimesulide, which is available in sachets containing 2 g of instant powder. It belongs to non-narcotic analgesics of category B, sold by prescription.

Recommended as a second-line anti-inflammatory and analgesic agent. Effectively eliminates pain of any etiology, helps reduce signs of inflammation during infection or injury.

Produced in India by the pharmaceutical company Kusum in several dosage forms that can be combined to achieve maximum effect:

• powder for suspension;
• pills;
• gel for external use.

Combination of Nimesil with other medications

If you are planning to combine Nimesil with any other medications, you should first consult a specialist. If you use this medicine together with some other drugs, firstly, it will increase the likelihood of bleeding, and secondly, their effect will be weakened.

For example, taking Nimesil along with antiplatelet medications is a bad idea, since this can greatly increase the likelihood of bleeding in the gastrointestinal tract.

If you take this medicine along with anticoagulants, their effect will be increased, but the likelihood of bleeding will also increase. So for those with impaired coagulation, NSAIDs are very rarely prescribed. If you need to take Nimesil, you should monitor blood clotting as carefully as possible.

When combining Nimesil with lithium preparations, it is also necessary to continuously monitor physical indicators. Taking a drug containing nimesulide makes the elimination of lithium slower, thereby increasing the concentration of this metal in the blood and its toxicity.

If you use Nimesil with methotrexate drugs, the negative effect of the latter also increases.

"Nimesil" is not allowed to be taken simultaneously with every drug

Using nimesulide preparations together with diuretics or furosemide is also not a very good idea: the effect of these two types of drugs will be weakened.

Analogues with a minimum of side effects

When choosing an NSAID, you need to take into account a large number of factors - the severity of pathological symptoms, age, and the presence of concomitant diseases. There are no medications without side effects, so it is very important to follow the instructions, choose the safest medications and use the minimum effective doses. You can replace Nimesil with over-the-counter analgesics, which have fewer unwanted effects and contraindications.

Ibuprofen

The international nonproprietary name is similar to the active ingredient - Ibuprofenum. According to its chemical structure, it is a derivative of propionic acid, which has a blocking effect on the COX enzyme and reduces the production of inflammatory mediators. The drug also helps eliminate fever and chills. Can be used during pregnancy and lactation as prescribed by a doctor. Special forms of ibuprofen have been developed in the form of syrup and suspension, which allows it to be prescribed to children after 3 months.

The most popular tablets from these manufacturers:

• Darnitsa, Ukraine;
• Borisov ZMP, Belarus;
• Borshchagovsky Chemical Plant, Ukraine;
• Akrikhin, Russian Federation;
• Hemofarm, Serbia;
• Tatchimpharmpreparaty, Russia.

Tablets contain 100, 200 or 400 mg of ibuprofen. The drug can be used for 2-3 weeks. Dosage regimen: 1 tablet 2 times a day, depending on the clinical situation.

Nalgesin

A modern analgesic-antipyretic containing 275 mg of naproxen in the form of sodium salt. The mechanism of action is associated with inhibition of the activity of enzymes involved in the synthesis of inflammatory mediators (prostaglandins and leukotrienes). This medicine also has antithrombotic properties. The drug has high bioavailability and is well tolerated by most patients.

According to the instructions, Naproxen is indicated for the treatment of radiculitis, ischalgia, radicular neuralgia, headache, muscle, joint and menstrual pain.

Contraindications:

• pregnancy and lactation;
• acute inflammatory diseases of the gastrointestinal tract (gastritis, duodenitis, peptic ulcer);
• intolerance to one of the components;
• bleeding disorders.

Undesirable effects when taking Nalgesin are associated with the individual characteristics of the body or an incorrectly selected dosage. They may manifest as a feeling of drowsiness and depression, abdominal discomfort, and dizziness.

The drug is produced in Slovenia by the company KRKA. A prescription is not required to purchase Nalgesin tablets.

Ketonal

The main active ingredient is ketoprofen. It is a representative of the latest generation of NSAIDs. In addition to blocking the action of all types of COX, it has the ability to inhibit the enzyme lipoxygenase. As a result, the concentration of bradykinin, prostaglandin and other inflammatory mediators decreases.

Indications for use:

• hyperthermia;
• infectious and inflammatory diseases of various localizations;
• acute and chronic pain.

The drug is contraindicated in cases of aspirin intolerance, bronchial asthma, gastric and duodenal ulcers, and increased bleeding.

Ketonal is available in capsules and tablets of 25, 150 and 200 mg. The presence of an injection form and a variety of dosages allows you to select the minimum effective dose, method and frequency of use of the drug. Ketonal can be used either as symptomatic therapy once or in a course of 2-3 weeks. Manufacturer: Lek DD, Slovenia.

Characteristics of the drug

Nimesil is a medicine that effectively fights inflammatory processes in the human skeletal system, tissues and joints. It also has antipyretic and analgesic properties. The active ingredient is nimesulide, and the additional components are ketomacrogol, maltodextrin and citric acid.

Nimesil is used for the following pathological conditions:

• toothache/headache, periodic female pain;
• acute respiratory diseases accompanied by high fever;
• period after surgery;
• closed fractures, sprains, bruises;
• rheumatism, spondylitis or any other joint disease of inflammatory etiology.

The release form of a drug from the group of non-steroidal anti-inflammatory drugs is granules. They are used to make a suspension for oral use, which is distinguished by its light yellow hue and citrus aroma.

The duration of treatment with Nimesil should be no more than 2 weeks (with daily intake of 1 sachet 2 times a day). The analgesic effect will last, on average, about 4-8 hours after a person drinks the suspension. This indicator may vary depending on individual tolerance to nimesulide.

The components that make up Nimesil allow the patient’s body to absorb it well. Therefore, side effects from taking it are rare.

But an overdose of the drug can provoke the following symptoms:

• painful sensations in the epigastric region;
• drowsiness and apathy;
• nausea, vomiting;
• stomach bleeding.

Less commonly observed are high blood pressure, renal dysfunction syndrome, and respiratory depression. If symptomatic therapy is started in time, these and other phenomena are reversible.

Reviews from doctors and patients

1. Andrey Viktorovich, dentist: “After opening the gumboil and removing a tooth, I always recommend that my patients take Nimesil, in addition to the antibiotic. After the anesthesia wears off, it effectively eliminates discomfort and swelling of the gums.”
2. Marina: “After cauterization of the cervical erosion, terrible pain appeared in the lower abdomen. The doctor advised me to drink a packet of Nise powder and then take these pills for a few days. It helped very quickly and well.”
3. Stepan: “Previously, at the first symptoms of colds and flu, I took Nimid in powder, but then problems with the liver began, I had to choose a more gentle drug. I switched to regular ibuprofen in domestically produced capsules. It relieves fever just as quickly and costs much less.”

When choosing a fast-acting analgesic, you should pay attention to the drug Nimesil; however, when using it, you need to familiarize yourself with the contraindications. This powder can be replaced by safer drugs, so the risks need to be assessed and compared with the expected benefits of its use.